How to induce ceramide synthesis in human skin?

Advanced Water S-100® surprises once again. Recently published by Drug Discoveries & Therapeutics, the advance publication's results suggest that electrolyzed reduced water S-100 enhances the expression on enzymes involved in the synthesis of ceramides containing ultra-long-chain fatty acid residues, which have a protective function in the skin.

Link: https://www.jstage.jst.go.jp/article/ddt/advpub/0/advpub_2021.01091/_pdf/-char/en